wiffle ball bat posted:

patty b was a gleeful guy tho

VectorSigma posted:

depression is likely an evolved response to stressful living conditions and the only reason it presents psychologically is its conflict with modern society oh and also a lot of things that get called depression are probably other mechanisms both physiological and mental that are poorly understood if at all and anyone with a cure for "depression" should be viewed as skeptically as anyone who claims to have a cure for cancer

wiffle ball bat posted:

theres that part of AS like 3/4 of the way through where it stops being funny and is just like 50 pages in a row of sadistic torture fantasies and i was like eh ill read something else

the movie is really good tho

Tarkus posted:

I dunno, as somebody who has suffered from actual depression, I've always viewed that feeling of desperation and overwhelming self-doubt and loathing to be a signal to change your life, to be better and learn something new. I've always wondered if this was a biological signal to do the exactly that, that your life was unsatisfactory and your own biological and evolutionary history was telling you to kick some rear end, even your own and be better.

I only say this because I'm fairly certain that various mental maladies affected people from time in memorial. It doesn't make sense from an evolutionary point of view to have people who are crippled mentally. There must be an actual advantage to depression as we know it. What it is, i have no idea.

numberoneposter posted:

the book is amazing too if you havnt gone through its a quick read i think i went through it in a day or two

Zzulu posted:

Tarkus posted:

I dunno, as somebody who has suffered from actual depression, I've always viewed that feeling of desperation and overwhelming self-doubt and loathing to be a signal to change your life, to be better and learn something new. I've always wondered if this was a biological signal to do the exactly that, that your life was unsatisfactory and your own biological and evolutionary history was telling you to kick some rear end, even your own and be better.

I only say this because I'm fairly certain that various mental maladies affected people from time in memorial. It doesn't make sense from an evolutionary point of view to have people who are crippled mentally. There must be an actual advantage to depression as we know it. What it is, i have no idea.

quote:

A Danish scientist

Tarkus posted:

I only say this because I'm fairly certain that various mental maladies affected people from time in memorial. It doesn't make sense from an evolutionary point of view to have people who are crippled mentally. There must be an actual advantage to depression as we know it. What it is, i have no idea.

Moridin920 posted:

lol pack it in folks

FRINGE posted:

People on the internet get really excited whenever a new excuse to not exercise comes up.

OPs buddy might have missed something, since at a basic level a lot of depression looks to be rooted in inflammation*, and exercise can lower systemic inflammation.

Unfortunately this conflicts with "shovel pizza, guzzle beer, sit on couch" so no one cares.



*This is a big thing being looked at, and its a massive thorn in the heart of the antidepressant "take them until you die" pill pusher crowd. It also overlaps with "being fat" since that is frequently coincident with inflammation.

http://www.ncbi.nlm.nih.gov/pubmed/21485745


Clinical depression is associated with a 30% increase of inflammation in the brain, according to a new study published in JAMA Psychiatry.
http://www.medicalnewstoday.com/articles/288715.php

Depression's Dance With Inflammation Why the body's natural protective response to injury, infection and stress may have unexpected emotional consequences.
http://discovermagazine.com/2014/julyaug/9-depressions-dance-with-inflammation

http://www.npr.org/sections/health-shots/2015/10/25/451169292/could-depression-be-caused-by-an-infection


Inflammatory conditions may precipitate or perpetuate depression, but the precise relationship is unclear
http://www.currentpsychiatry.com/th...e08701d6dc.html

numberoneposter posted:

it depends

climbers look emaciated

LegoPirateNinja posted:

not all climbers look like that

Tarkus posted:

I dunno, as somebody who has suffered from actual depression, I've always viewed that feeling of desperation and overwhelming self-doubt and loathing to be a signal to change your life, to be better and learn something new. I've always wondered if this was a biological signal to do the exactly that, that your life was unsatisfactory and your own biological and evolutionary history was telling you to kick some rear end, even your own and be better.

I only say this because I'm fairly certain that various mental maladies affected people from time in memorial. It doesn't make sense from an evolutionary point of view to have people who are crippled mentally. There must be an actual advantage to depression as we know it. What it is, i have no idea.

Oberleutnant posted:

https://en.wikipedia.org/wiki/Climbing_specialist

come on dude, keep up

Oberleutnant posted:

https://en.wikipedia.org/wiki/Climbing_specialist

come on dude, keep up

Frostwerks posted:

post sources please because im interested in if there is any veracity in this at all

quote:

But there's nothing weird or abnormal about Kate. She is one of an enormous number of people with a similar constellation of symptoms - millions of people at the end of their physical, and spiritual, tether. Frank Lipman, a South African doctor working in New York, has identified the condition in hundreds of his patients - he has a word for it: "spent". Lipman says that feeling spent is an understandable response to the 21st century. If you put a human being in a modern city, and add computers, mobile phones, credit cards, neon lights and 24-hour shopping, he says, what do you expect?

...

But the medical establishment couldn't find anything wrong with Greg. He had batteries of tests. His organs all functioned well. He did not have cancer, heart disease, or even high blood pressure. Eventually, Ben Turner, a consultant at London Bridge Hospital, put him on a low dose of an antidepressant similar to Prozac. Greg says, "He said: 'Well, you may not be feeling depressed psychologically, but I can bet you that your body is chemically depressed.' He couldn't identify what was doing this to me. He said the antidepressant would act as some kind of trigger to my metabolism, to bring it back to life. And it worked. For a while, at least."

Greg gradually got better, over a period of six months. The veil of exhaustion lifted; he started functioning again. He was fine for several months. Then it happened again - the aches, the fevers, the inability to get out of bed. The zombie-like sessions in front of the TV. And what had Greg been doing? Just working in an office. "There's got to be something we're not seeing," he says. "Look at what happened to me - I felt half-dead, and the thing that brought me back to life was an anti-depressant. So this thing is partly psychological. It's generated by nothing more than normal life - a lifetime of hitting deadlines in offices, of your constantly beeping BlackBerry; But it's more than that. I would find myself in the supermarket, surrounded by bright fluorescent lighting and rivers of people, all these people arguing about what to buy. And all that stuff on the shelves. Thousands of products. And sometimes I'd look at all these people on the go, moving about, all the aggression and urgency, and I would feel completely alienated from all of it. Like I didn't want to belong at all."

...

"A person's total load," writes Dr Frank Lipman, "is the total amount of physical, psychological and environmental stress on his or her body. In the past 30 years this total load on the human body has quadrupled.

"My philosophy," Lipman tells me, "is that we are out of sync with our body rhythms." By "we" he means people in the developed world, which has been ruled by clocks and artificial light for more than 100 years. Human beings, he believes, evolved to sleep when it was dark and wake up when it was light. "We're also overfed and undernourished with food, and undernourished when it comes to light."

...

And there does not seem to be a way out. Madeleine Bunting, the author of Willing Slaves, a brilliant analysis of our culture of overwork, puts it simply. We live in a world, she tells me, where "nothing is enough". Driven by debt, we need to work harder all the time. Crushed by overwork, our relationships begin to break down. Robbed of the healing balm of relationships, we become more and more insecure and exhausted. More and more exhausted, we become less efficient at our jobs, which makes us more insecure, and so on. In our heads, we are always thinking about what's just ahead rather than what's happening now. "We are out of the now," Bunting tells me, "which is an exhausting place to be."

quote:

Work that Dr. McEwen and his colleagues have conducted with rats nicely illustrates this wear-and-tear effect. In the studies, the rats were placed in a small compartment, their movement restricted for six hours a day during their normal resting time. The first time the rats were restrained, Dr. McEwen said, their cortisol levels rose as their stress response moved into full gear. But after that, their cortisol production switched off earlier each day as they became accustomed to the restraint.

That might have been the end of the story. But the researchers also found that at 21 days, the rats began to show the effects of chronic stress. They grew anxious and aggressive. Their immune systems became slower to fight off invaders. Nerve cells in the hippocampus, a brain region involved in memory, atrophied. The production of new hippocampal neurons stopped.

...

But high levels of cortisol, studies have shown, can shrink nerve cells in the hippocampus and halt the creation of new hippocampal neurons. These changes are associated with aging and memory problems. Some evidence also links a smaller hippocampus with post-traumatic stress disorder, depression and sexual abuse in childhood, though the meaning of this size difference is still being debated.

...

A direct link between stress and more serious diseases, however, has been more difficult to establish, Dr. Cohen said. Recent studies have provided increased support for the notion that stress contributes to heart disease, and researchers have tied psychological stress, directly or indirectly, to diabetes, rheumatoid arthritis, fibromyalgia, severe depression and other mental disorders.

quote:

Chronic Stress Can Cause Fever And Fatigue

The exigencies of modern life after paradise — relationships, finances, health — often trigger stress affecting the body’s serotonin system responsible for regulating mood, sleep, and appetite. Body temperature rises and the heart starts pumping faster as a “fight or flight” response to possible physical threats in the environment. Yet this stress-induced hyperthermia (SIH) may endure far beyond any practical purpose, developing into a chronic condition known as psychogenic fever characterized by extreme fatigue. A new study published in the journal Cell Metabolism uncovers the neural pathways associated with SIH that are likely linked to the chronic stress condition.

...

Although the body was designed to handle acute levels of stress, chronic stress conditions bringing high level of the hormone cortisol have been linked to the development of major chronic diseases such as obesity and diabetes, according to the Centers for Disease Control and Prevention.

Frostwerks posted:

seriously tho wtf is this from

FRINGE posted:

MXCLVIII

Oberleutnant posted:

one-thousand-ninety-fifty-eight??? that's not a number you loving fraud