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I thought you guys might be curious to see how two genetic test companies compared. I got kind of different results from each, but before I share, I will post a pic of my dog so you can take a guess as to his breed mix, if you want. He is 18 years old, and 60lbs.  Ok, on to the results: The first is Embark, about $180 with a coupon / referral code. (Here's mine if you want it) It's a more comprehensive (and expensive) test with some additional genetic testing which told me he was negative for about 140 different things.   Next is Wisdom Panel, a bit cheaper at $80.   Rat terrier on this one...? One thing I didn't know is that this is "3.0" when there's a "4.0" Wisdom Panel version available. D'oh, I would have got it if I had known. Embark, the more expensive one says they'll send you new results as their research improves. Conclusion: He's a mutt. Wolfiness doesn't mean he's a wolf hybrid, it just means some ancient alleles are still present. Most dogs are less than 1%. He's also <1% inbred, a very low amount, even for mixed breeds. Other stuff for genetics nerds: Maternal Haplotype is A1d, Haplogroup A11a. Paternal Haplotype A1a, group H1a.15. I can share more of the technical results if anyone is interested.
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Oct 10, 2018 21:40
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Ugh, I want to do the embark so bad but I can't justify spending the money. Thanks for sharing the results on your 120 year old man there! He looks like a fine assortment 
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Oct 11, 2018 03:05
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Instant Jellyfish posted:Ugh, I want to do the embark so bad but I can't justify spending the money. Thanks for sharing the results on your 120 year old man there! He looks like a fine assortment Thanks, it seemed worthwhile as he isn't going to be around forever. The last few months he's really showing his age.
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Oct 11, 2018 03:32
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Thanks for sharing this! I work at a veterinary clinic that offers canine genetic testing analyses, and I'd wondered exactly how up-and-up that sort of thing is, so it's really interesting to see two results from two labs from the same dog. The same very good and handsome dog I might add. 
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Oct 11, 2018 04:42
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WICKEDLY A BIRD posted:Thanks for sharing this! I work at a veterinary clinic that offers canine genetic testing analyses, and I'd wondered exactly how up-and-up that sort of thing is, so it's really interesting to see two results from two labs from the same dog. I think they're reputable, just results may vary. I can't really tell if one is better than the other for obvious reasons, but Embark says they are affiliated with Cornell & test more things. Might be easier with less of a multi-generation mutt.
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Oct 11, 2018 06:28
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Charles posted:Other stuff for genetics nerds: Maternal Haplotype is A1d, Haplogroup A11a. Paternal Haplotype A1a, group H1a.15. I can share more of the technical results if anyone is interested. You might as well, more detail = better than. Thanks for sharing, always been curious about this.
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Oct 12, 2018 02:36
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that's really cool tbh. the ancient alleles could come from the australian cattledog, they have pretty recent pure dingo ancestry (late nineteenth century iirc) and koolies i think are even heavier on the dingo blood, being closer to kelpies. your dude definitely has cattledog in him by the look of him but i'm not sure about koolie, it could be the ancestral closeness between the two breeds confusing things. he's a handsome and good boy
incredible flesh fucked around with this message at 02:47 on Oct 12, 2018 |
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Oct 12, 2018 02:44
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18 years old! What a cool old man. Thanks for sharing!
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Oct 16, 2018 00:44
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Gluten Freeman posted:18 years old! What a cool old man. Thanks for sharing! Age doesn't get you dignity! 
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Oct 19, 2018 03:42
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Seat Safety Switch posted:You might as well, more detail = better than. Thanks for sharing, always been curious about this. I can link to some of the info: https://my.embarkvet.com/dog/otis63 (Please don't doxx me or my dog) What you can't see on that link: Breed This is an image of where on his chromosomes they found the different breed traits.  Information on inbreeding:  Traits Some random genetic info. As you can see, it can show other dogs with similar genetics for you to compare to. I don't quite see any that look like Otis.     Health Otis is a carrier of Progressive rod-cone degeneration, a progressive vision loss. Carrier means that he has one of the genes, not two, so he would need to mate with another carrier of the gene and have their offspring have both the genes. PRCD Exon 1 -- GA -- (AA would be expressive of the disease). Something written on the vet report but I can't find on the regular results is his liver ALT value may be baseline lower than average. I'll have to ask the vet to look at his older bloodwork to see if it's right. I'll write what he tested clear for at the bottom of this post as it's a long list! Compared to actual health: I got him when he was 12, so I don't know his full history, but I can tell you the past six years. He already was in need of a dental and has had a few over the past years, including removing some cracked teeth. Edit: he had arthritis, but until now had managed it pretty well. When I met him he was a bit overweight and out of shape. At age 16 he had a melanoma removed from his leg. Now, at age 18, his years are really catching up to him. Since the beginning of the year, he's really been slowing down. Bloodwork this summer shows the beginning of kidney disease. Something else seems to be going on, and his appetite has been low the past week or so. I'm awaiting the radiologist report, but he might have something on his lymph node.... Otis tested CLEAR for all these conditions: (wish you could make this collapsible like on some forums) • MDR1 Drug Sensitivity (MDR1) (Chromosome 14) • P2Y12 Receptor Platelet Disorder (P2RY12) (Chromosome 23) • Factor IX Deficiency, Hemophilia B (F9 Exon 7, Terrier Variant) (Chromosome X) • Factor IX Deficiency, Hemophilia B (F9 Exon 7, Rhodesian Ridgeback Variant) (Chromosome X) • Factor VII Deficiency (F7 Exon 5) (Chromosome 22) • Factor VIII Deficiency, Hemophilia A (F8 Exon 10, Boxer Variant) (Chromosome X) • Factor VIII Deficiency, Hemophilia A (F8 Exon 11, Shepherd Variant 1) (Chromosome X) • Factor VIII Deficiency, Hemophilia A (F8 Exon 1, Shepherd Variant 2) (Chromosome X) • Thrombopathia (RASGRP2 Exon 5, Basset Hound Variant) (Chromosome 18) • Thrombopathia (RASGRP2 Exon 8) (Chromosome 18) • Thrombopathia (RASGRP2 Exon 5, American Eskimo Dog Variant) (Chromosome 18) • Von Willebrand Disease Type II (VWF Exon 28) (Chromosome 27) • Von Willebrand Disease Type III (VWF Exon 4) (Chromosome 27) • Von Willebrand Disease Type I (VWF) (Chromosome 27) • Canine Leukocyte Adhesion Deficiency Type III (LAD3) (FERMT3) (Chromosome 18) • Congenital Macrothrombocytopenia (TUBB1 Exon 1, Cavalier King Charles Spaniel Variant) (Chromosome 24) • Canine Elliptocytosis (SPTB Exon 30) (Chromosome 8) • Cyclic Neutropenia, Gray Collie Syndrome (AP3B1 Exon 20) (Chromosome 31) • Glanzmann's Thrombasthenia Type I (ITGA2B Exon 12) (Chromosome 9) • May-Hegglin Anomaly (MYH9) (Chromosome 10) • Prekallikrein Deficiency (KLKB1 Exon 8) (Chromosome 16) • Pyruvate Kinase Deficiency (PKLR Exon 5) (Chromosome 7) • Pyruvate Kinase Deficiency (PKLR Exon 7 Labrador Variant) (Chromosome 7) • Pyruvate Kinase Deficiency (PKLR Exon 7 Pug Variant) (Chromosome 7) • Pyruvate Kinase Deficiency (PKLR Exon 7 Beagle Variant) (Chromosome 7) • Pyruvate Kinase Deficiency (PKLR Exon 10) (Chromosome 7) • Trapped Neutrophil Syndrome (VPS13B) (Chromosome 13) • Ligneous Membranitis (PLG) (Chromosome 1) • Congenital Hypothyroidism (TPO, Tenterfield Terrier Variant) (Chromosome 17) • Complement 3 (C3) deficiency (C3) (Chromosome 20) • Severe Combined Immunodeficiency (PRKDC) (Chromosome 29) • Severe Combined Immunodeficiency (RAG1) (Chromosome 18) • X-linked Severe Combined Immunodeficiency (IL2RG Variant 1) (Chromosome X) • X-linked Severe Combined Immunodeficiency (IL2RG Variant 2) (Chromosome X) • Progressive Retinal Atrophy - rcd1 Rod-cone dysplasia, rcd1 (PDE6B Exon 21 Irish Setter Variant) (Chromosome 3) • Progressive Retinal Atrophy Rod-cone dysplasia, rcd1a (PDE6B Exon 21 Sloughi Variant) (Chromosome 3) • Progressive Retinal Atrophy - rcd3 Rod-cone dysplasia, rcd3 (PDE6A) (Chromosome 4) • Progressive Retinal Atrophy - CNGA (CNGA1 Exon 9) (Chromosome 13) • Progressive Retinal Atrophy (CNGB1) (Chromosome 2) • Progressive Retinal Atrophy (SAG) (Chromosome 25) • Golden Retriever Progressive Retinal Atrophy 2 (TTC8) (Chromosome 8) • Progressive Retinal Atrophy - crd1 (PDE6B) (Chromosome 3) • Progressive Retinal Atrophy - crd2 (IQCB1) (Chromosome 33) • Progressive Retinal Atrophy - crd4/cord1 (RPGRIP1) (Chromosome 15) • Collie Eye Anomaly, Choroidal Hypoplasia (NHEJ1) (Chromosome 37) • Achromatopsia (CNGA3 Exon 7 German Shepherd Variant) (Chromosome 10) • Achromatopsia (CNGA3 Exon 7 Labrador Retriever Variant) (Chromosome 10) • Autosomal Dominant Progressive Retinal Atrophy (RHO) (Chromosome 20) • Canine Multifocal Retinopathy cmr1 (BEST1 Exon 2) (Chromosome 18) • Canine Multifocal Retinopathy cmr2 (BEST1 Exon 5) (Chromosome 18) • Canine Multifocal Retinopathy cmr3 (BEST1 Exon 10 Deletion) (Chromosome 18) • Canine Multifocal Retinopathy cmr3 (BEST1 Exon 10 SNP) (Chromosome 18) • Glaucoma Primary Open Angle Glaucoma (ADAMTS10 Exon 9) (Chromosome 20) • Glaucoma Primary Open Angle Glaucoma (ADAMTS10 Exon 17) (Chromosome 20) • Glaucoma Primary Open Angle Glaucoma (ADAMTS17 Exon 11) (Chromosome 3) • Glaucoma Primary Open Angle Glaucoma (ADAMTS17 Exon 2) (Chromosome 3) • Hereditary Cataracts, Early-Onset Cataracts, Juvenile Cataracts (HSF4 Exon 9 Boston Terrier Variant) (Chromosome 5) • Hereditary Cataracts, Early-Onset Cataracts, Juvenile Cataracts (HSF4 Exon 9 Shepherd Variant) (Chromosome 5) • Primary Lens Luxation (ADAMTS17) (Chromosome 3) • Congenital stationary night blindness (RPE65) (Chromosome 6) • Macular Corneal Dystrophy (MCD) (CHST6) (Chromosome 5) • 2,8-Dihydroxyadenine (2,8-DHA) Urolithiasis (APRT) (Chromosome 5) • Cystinuria Type I-A (SLC3A1) (Chromosome 10) • Cystinuria Type II-A (SLC3A1) (Chromosome 10) • Cystinuria Type I-A (SLC7A9) (Chromosome 1) • Hyperuricosuria and Hyperuricemia or Urolithiasis (SLC2A9) (Chromosome 3) • Polycystic Kidney Disease (PKD1) (Chromosome 6) • Primary Hyperoxaluria (AGXT) (Chromosome 25) • Protein Losing Nephropathy (NPHS1) (Chromosome 1) • X-Linked Hereditary Nephropathy (Samoyed Variant 2) (COL4A5 Exon 35) (Chromosome X) • Autosomal Recessive Hereditary Nephropathy, Familial Nephropathy (COL4A4 Exon 3) (Chromosome 25) • Primary Ciliary Dyskinesia (CCDC39 Exon 3) (Chromosome 34) • Congenital Keratoconjunctivitis Sicca and Ichthyosiform Dermatosis (CKCSID), Dry Eye Curly Coat Syndrome (FAM83H Exon 5) (Chromosome 13) • X-linked Ectodermal Dysplasia, Anhidrotic Ectodermal Dysplasia (EDA Intron 8) (Chromosome X) • Renal Cystadenocarcinoma and Nodular Dermatofibrosis (RCND) (FLCN Exon 7) (Chromosome 5) • Glycogen Storage Disease Type II, Pompe's Disease (GAA) (Chromosome 9) • Glycogen Storage Disease Type Ia, Von Gierke Disease (G6PC) (Chromosome 9) • Glycogen Storage Disease Type IIIa (GSD IIIa) (AGL) (Chromosome 6) • Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A (SGSH Exon 6 Variant 1) (Chromosome 9) • Mucopolysaccharidosis Type IIIA, Sanfilippo Syndrome Type A (SGSH Exon 6 Variant 2) (Chromosome 9) • Mucopolysaccharidosis Type VII, Sly Syndrome (GUSB Exon 5) (Chromosome 6) • Mucopolysaccharidosis Type VII, Sly Syndrome (GUSB Exon 3) (Chromosome 6) • Glycogen storage disease Type VII, Phosphofructokinase deficiency (PFKM Exon 21) (Chromosome 27) • Glycogen storage disease Type VII, Phosphofructokinase deficiency (PFKM Exon 8) (Chromosome 27) • Lagotto Storage Disease (ATG4D) (Chromosome 20) • Neuronal Ceroid Lipofuscinosis 1 (PPT1 Exon 8) (Chromosome 15) • Neuronal Ceroid Lipofuscinosis 2 (TPP1 Exon 4) (Chromosome 21) • Neuronal Ceroid Lipofuscinosis 1, Cerebellar Ataxia - NCL-A (ARSG Exon 2) (Chromosome 9) • Neuronal Ceroid Lipofuscinosis 1 (CLN5 Exon 4 Variant 1) (Chromosome 22) • Neuronal Ceroid Lipofuscinosis 6 (CLN6 Exon 7) (Chromosome 30) • Neuronal Ceroid Lipofuscinosis 8 (CLN8 Exon 2) (Chromosome 37) • Neuronal Ceroid Lipofuscinosis (MFSD8) (Chromosome 19) • Neuronal Ceroid Lipofuscinosis (CLN8) (Chromosome 37) • Neuronal Ceroid Lipofuscinosis 10 (CTSD Exon 5) (Chromosome 18) • Neuronal Ceroid Lipofuscinosis (CLN5 Exon 4 Variant 2) (Chromosome 22) • Adult-Onset Neuronal Ceroid Lipofuscinosis (ATP13A2) (Chromosome 2) • GM1 Gangliosidosis (GLB1 Exon 15 Shiba Inu Variant) (Chromosome 23) • GM1 Gangliosidosis (GLB1 Exon 15 Alaskan Husky Variant) (Chromosome 23) • GM1 Gangliosidosis (GLB1 Exon 2) (Chromosome 23) • GM2 Gangliosidosis (HEXB, Poodle Variant) (Chromosome 2) • GM2 Gangliosidosis (HEXA) (Chromosome 30) • Globoid Cell Leukodystrophy, Krabbe disease (GALC Exon 5) (Chromosome 8) • Autosomal Recessive Amelogenesis Imperfecta (Italian Greyhound Variant) (Chromosome 13) • Persistent Mullerian Duct Syndrome (AMHR2) (Chromosome 27) • Shar-Pei Autoinflammatory Disease (SPAID, Shar-Pei Fever) (MTBP) (Chromosome 13) • Alaskan Husky Encephalopathy, Subacute Necrotizing Encephalomyelopathy (SLC19A3) (Chromosome 25) • Alexander Disease (GFAP) (Chromosome 9) • Cerebellar Abiotrophy, Neonatal Cerebellar Cortical Degeneration (SPTBN2) (Chromosome 18) • Cerebellar Ataxia, Progressive Early-Onset Cerebellar Ataxia (SEL1L) (Chromosome 8) • Cerebellar Hypoplasia (VLDLR) (Chromosome 1) • Spinocerebellar Ataxia, Late-Onset Ataxia (CAPN1) (Chromosome 18) • Spinocerebellar Ataxia with Myokymia and/or Seizures (KCNJ10) (Chromosome 38) • Benign Familial Juvenile Epilepsy, Remitting Focal Epilepsy (LGI2) (Chromosome 3) • Degenerative Myelopathy (SOD1A) (Chromosome 31) • Fetal-Onset Neonatal Neuroaxonal Dystrophy (MFN2) (Chromosome 2) • Hypomyelination and Tremors (FNIP2) (Chromosome 15) • Shaking Puppy Syndrome, X-linked Generalized Tremor Syndrome (PLP) (Chromosome X) • L-2-Hydroxyglutaricaciduria (L2HGDH) (Chromosome 0) • Neonatal Encephalopathy with Seizures (NEWS) (ATF2) (Chromosome 36) • Polyneuropathy, NDRG1 Greyhound Variant (NDRG1 Exon 15) (Chromosome 13) • Polyneuropathy, NDRG1 Malamute Variant (NDRG1 Exon 4) (Chromosome 13) • Narcolepsy (HCRTR2 Intron 6) (Chromosome 12) • Progressive Neuronal Abiotrophy (Canine Multiple System Degeneration) (SERAC1 Exon 15) (Chromosome 1) • Progressive Neuronal Abiotrophy (Canine Multiple System Degeneration) (SERAC1 Exon 4) (Chromosome 1) • Hereditary Sensory Autonomic Neuropathy (HSAN), Acral Mutilation Syndrome (GDNF-AS) (Chromosome 4) • Juvenile-Onset Polyneuropathy, Leonberger Polyneuropathy 1 (LPN1, ARHGEF10) (Chromosome 16) • Dilated Cardiomyopathy (PDK4) (Chromosome 14) • Long QT Syndrome (KCNQ1) (Chromosome 18) • Muscular Dystrophy Cavalier King Charles Spaniel Variant 1 (Chromosome X) • Muscular Dystrophy Muscular Dystrophy (DMD Pembroke Welsh Corgi Variant ) (Chromosome X) • Muscular Dystrophy Muscular Dystrophy (DMD Golden Retriever Variant) (Chromosome X) • Centronuclear Myopathy (PTPLA) (Chromosome 2) • Exercise-Induced Collapse (DNM1) (Chromosome 9) • Inherited Myopathy of Great Danes (BIN1) (Chromosome 19) • Myotonia Congenita (CLCN1 Exon 7) (Chromosome 16) • Myotonia Congenita (CLCN1 Exon 23) (Chromosome 16) • Myotubular Myopathy 1, X-linked Myotubular Myopathy (MTM1) (Chromosome X) • Hypocatalasia, Acatalasemia (CAT) (Chromosome 18) • Pyruvate Dehydrogenase Deficiency (PDP1) (Chromosome 29) • Malignant Hyperthermia (RYR1) (Chromosome 1) • Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 53) (Chromosome 2) • Imerslund-Grasbeck Syndrome, Selective Cobalamin Malabsorption (CUBN Exon 8) (Chromosome 2) • Congenital Myasthenic Syndrome (CHAT) (Chromosome 28) • Congenital Myasthenic Syndrome (COLQ) (Chromosome 23) • Episodic Falling Syndrome (BCAN) (Chromosome 7) • Dystrophic Epidermolysis Bullosa (COL7A1) (Chromosome 20) • Ectodermal Dysplasia, Skin Fragility Syndrome (PKP1) (Chromosome 7) • Ichthyosis, Epidermolytic Hyperkeratosis (KRT10) (Chromosome 9) • Ichthyosis (PNPLA1) (Chromosome 12) • Ichthyosis (SLC27A4) (Chromosome 9) • Focal Non-Epidermolytic Palmoplantar Keratoderma, Pachyonychia Congenita (KRT16) (Chromosome 9) • Hereditary Footpad Hyperkeratosis (FAM83G) (Chromosome 5) • Hereditary Nasal Parakeratosis (SUV39H2) (Chromosome 2) • Musladin-Lueke Syndrome (ADAMTSL2) (Chromosome 9) • Cleft Lip and/or Cleft Palate (ADAMTS20) (Chromosome 27) • Hereditary Vitamin D-Resistant Rickets (VDR) (Chromosome 27) • Oculoskeletal Dysplasia 1, Dwarfism-Retinal Dysplasia (COL9A3, Labrador Retriever) (Chromosome 24) • Osteogenesis Imperfecta, Brittle Bone Disease (COL1A2) (Chromosome 14) • Osteogenesis Imperfecta, Brittle Bone Disease (SERPINH1) (Chromosome 21) • Osteogenesis Imperfecta, Brittle Bone Disease (COL1A1) (Chromosome 9) • Osteochondrodysplasia, Skeletal Dwarfism (SLC13A1) (Chromosome 14) • Skeletal Dysplasia 2 (COL11A2) (Chromosome 12) • Craniomandibular Osteopathy (CMO) (SLC37A2) (Chromosome 5) Kia Soul Enthusias fucked around with this message at 05:11 on Oct 19, 2018 |
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Oct 19, 2018 04:47
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Sounds like he is genetically pretty healthy. I hope the radiology report comes back clear for Otis. Thanks for the extra info! It is cool to see. Seat Safety Switch fucked around with this message at 16:31 on Oct 19, 2018 |
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Oct 19, 2018 16:27
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Seat Safety Switch posted:Sounds like he is genetically pretty healthy. I hope the radiology report comes back clear for Otis. Ultrasound today shows a big mass where his right kidney should be Surgery may be possible but I'm not holding out hope. :/
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Oct 25, 2018 04:32
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Charles posted:Ultrasound today shows a big mass where his right kidney should be Gonna do a CT scan this Friday to get more info. $$, but hopefully worth it.
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Oct 30, 2018 03:29
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Oh no Otis  Fingers crossed for you.
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Oct 30, 2018 03:31
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Charles posted:Gonna do a CT scan this Friday to get more info. $$, but hopefully worth it. Let us know 
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Nov 2, 2018 04:00
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LITERALLY A BIRD posted:Let us know His kidney values have spiked, the contrast they use for the CT would be very hard on his kidneys, they offered to keep him in the hospital this weekend and give him fluids and stuff, but I think I better take him home.
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Nov 2, 2018 22:49
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My thoughts are with you guys. Spoil him just a little bit extra for me. 
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Nov 3, 2018 04:28
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