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Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding@Home is beta testing a new GPU folding core which supports both CUDA and OpenCL. It gives a speed boost on all Nvidia GPUs, especially on the lower core count GPUs: 1660 Super:31%, 1080Ti:25%, 2080Ti:20% or 3080:14%. Due to the quick return bonus, even though the relative speedup is higher on the lower tier cards, the actual points boost will be higher on the bigger cards. Looking forward to this going live so my 1660 Super folds faster than the RX 5600 XT.

Unfortunately, low atom count work units still under-utilize the bigger cards, but they're working on segmenting GPUs better in the future, so they'll get work units more suited to their core count.

Edit: I tried running BOINC on a couple of Android devices, but while I did return some valid results in the WCG Covid-19 project, I got a lot of work units that failed due to segfaults, so I gave up. It was a cheap phone and a cheap Asus pad, so they might have had instability in anything from Android to the storage.

Vir fucked around with this message at 11:44 on Sep 28, 2020

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Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding@Home has released the CUDA folding core. There are also some bug fixes for AMD cards, but with this the Nvidia cards have an even bigger advantage for folding.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Zarin posted:

Yeah it's super dumb (in a good way!). I went from 540k PPD to over 1.05m overnight. Absolutely silly.
1660 Ti owners got a 270% improvement or something. My 1660 Super is now faster than the best AMD card.

AMD's engineers better get working on those ROCm drivers and see if they can optimize them for folding without hurting the more memory intensive compute tasks.

Zarin posted:

Is there any reason why I *shouldn't* run Folding@Home on my CPU?
If you have a low core count CPU without AVX support, you probably shouldn't CPU fold. Also, if your CPU clocks down too much, it starts to bottleneck the GPU folding - at least it used to under OpenCL. So if you are GPU folding with an old CPU you might want to see if your toal system PPD rises with or without CPU folding enabled.

CPU folding is less energy efficient than GPU folding, so if you need to run your air conditioner, then you should probably pause CPU folding until the weather gets colder.

Even so, Folding@Home needs CPU folders, so CPU folding isn't dead.

If you have a fairly modern Ryzen or Threadripper CPU with SMT, the most efficient number of threads appears to be 2 below the CPU's thread count, and subtract 2 threads per GPU. So if you're only CPU folding on a 32 thread Ryzen 9 3950X, the most efficient setup is folding on 30 threads. If you have one GPU as well, then 28 or 26 CPU threads is better. A Ryzen 5 3600 running a GPU is best run with 8 threads. CUDA might have changed this, so we might to check. The CUDA core still shows 100% CPU utilization, but this is just an active wait state, so real testing is needed to see if you can now fold with more CPU threads together with the GPU.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


If you check the logs, you'll probably see many instances of the folding core automatically dropping down to 8 folding threads because it doesn't like a number of threads which is divisible by 5, 7 or other large primes.

Edit: Your CPU has AVX2, which means it should be pretty good for folding.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


That's weird, which OS?

If you're already maxed out doing BOINC, it might not be worth the time to set up Folding as well, but I've never heard of hibernation being interrupted by folding. I do know that the "on idle" setting has very mixed results, especially with GPU folding, and that sometimes manually pausing the GPU folding or making a script for it works better than idle detection.

Folding is actually a bit time sensitive, especially the current "Moonshot" project sprints, which only gives you like 24 hours to complete a work unit. So if you don't use your computer most every day, folding might not be suited for it.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


You might try to set the "disable-sleep-when-active" to "false" in the Expert tab in your client configuration. That would allow you to use Sleep, but you should check if the GPU core correctly resumes from checkpoint when it wakes up again, or if it just abandons the work unit.

The reason for this issue seems to be that Sleep and Hibernate doesn't store the contents of the GPU's VRAM, only the state of CPU processes, so FAH "solves" it by blocking the sleep function while GPU folding. It's apparently hard to program around too, because of the GPU permissions that Windows gives to applications. Same reason why you shouldn't be folding on Remote Desktop, but should be physically logged in. (You can start new GPU work units while logged into Remote Desktop, but if you log out it won't start a new one when the current WU finishes.)

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


BurritoJustice posted:

now when I go to fold the CPU is running around the same but the GPUs are sitting on like, 10k each. Which is obviously not worth it for the electricity used. Does anyone have any ideas?
Does that persist across several work units and projects? Remember that the Quick Return Bonus is dependent on how quickly you return a work unit, and if you stop folding to fix a computer problem, the PPD will be low until you finish that work unit. The effect will be especially harsh if you just barely was making the Timeout before the crash, and now only is able to return the work unit within the Expiry time.

If you return a work unit after Timeout, but before Expiry, you will still get some credit but the WU will be re-issued to someone else. And if you return before Timeout, your QRB is higher the faster you return it.

COVID-19 Moonshot work units have especially short timeouts because they are so time-critical. Researchers are using the data to prioritize chemical compounds to synthesize and assay in-vitro. More traditional projects have longer timeouts on them.

Can you try pausing the CPU and see if the GPUs start working again? Two CPU threads should be dedicated to feeding the GPUs with work and sanity-chekcing their results.

If your PPD permanently dropped, then I'd suspect some kind of hardware issue. Have you asked in the foldingforum.org forums?

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding work units are not supposed to be done by two folders. The only cases where a work unit is issued to more than one folder is if it passes timeout, it crashes, gets dumped or there's something wrong with the work server.

The servers validate the work on their own, because it takes relatively little computation to validate the folding work once it has been done.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding@home has quietly released a new client version (7.6.20), and there is now an ARM Linux / Raspberry Pi version as well: https://foldingathome.org/alternative-downloads/

e: Also they posted some science news: https://foldingathome.org/2020/10/20/covid-moonshot-sprint-4/

quote:

Just as we were doing this, something extremely unexpected happened: The chirally-separated version of the compound we started with turned out be 100 nM! That’s 25 times more potent (meaning you need 25x less drug to get the same effect in shutting down the protease) than what we thought we started from!

The exciting aspect of this is that we have apparently been working on an extremely potent compound series all along in Sprint 4, thinking it was “just” a backup series. All of the work we did has suddenly become much more important.

The starting materials we ordered from Sprint 4 have already arrived at the Weizmann, and the London lab is already hard at work synthesizing new compounds based on Sprint 4 designs. We’re excited to be able to share the results with you once they start trickling in.

Vir fucked around with this message at 10:39 on Oct 20, 2020

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding at Home is running a 20 year anniversary stream on Twitch: https://twitch.tv/videos/807519293
e: Link to replay.

Vir fucked around with this message at 12:34 on Nov 19, 2020

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


There is a security vulnerability that affects those who use the Folding@Home GUI prior to version 7.6.20 to control remote folding instances over insecure networks: https://foldingathome.org/2020/11/23/update-for-those-using-advanced-remote-client-management-configurations/

Basically, the folding client or an attacker on the folding client's network could trick the GUI into running arbitrary code. This doesn't matter to those who fold on their own computers, but maybe if you're running folding on your webserver or something and just opened it up to the world.

mdxi posted:

Sometime in the past few days I hit 100 years of CPU time for WCG's Mapping Cancer Markers project
I'll have you know that I've simulated a whopping 0.000042 seconds of proteins jiggling.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


I fold on my game computer while I'm not gaming, and fold on some e-waste machines for additional heating in the winter time.

Tuxide posted:

In Folding@home, we are still #68 in rankings. Its compute power is now about 240 petaFLOPS, a shadow of the 2.62 exaFLOPS it was back towards the end of April.
They over-estimated the exaFLOP count for F@h, because they were counting a lot of institutional or company contributors who spawned a new instance for every work unit computed. Additionally, it took into account a too large time interval. If you look at the amount of points, the compute power has only dropped from about 1.2 billion per month at the April peak to about 0.9 billion per month now.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Dr. Bowman shares some of the F@H results so far. They are moving into animal testing of candidates for therapeutic compounds. https://www.youtube.com/watch?v=6w8xb__A8Gc

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Folding@Home simulations might have found a way to disable a bunch of coronaviruses, like SARS-CoV-2 (Covid-19), SARS-CoV-1 and MERS. They might even have found a therapeutic for the common cold. https://foldingathome.org/2020/12/16/sars-cov-2-nsp16-activation-mechanism-and-a-cryptic-pocket-with-pan-coronavirus-antiviral-potential/

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


mdxi posted:

That is work right there. Protein engineering is getting really, really interesting.

Here's a status update on this. They hope to have a clinical candidate this month.
https://www.youtube.com/watch?v=fH0hIXC3bUg

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


Will this allow MacOS and ARM Linux users to use GPUs for Open Pandemics?

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


There are some old Mac Pros with discrete AMD GPUs in them, and even some from Nvidia before that, but Folding@Home doesn't support any of them because there was a bug in OpenCL for MacOS back when it was more worthwhile, and MacOS has deprecated OpenCL and replaced it with Apple's own Metal API.

Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


The F@H statistics page has been given a makeover. It now displays team logos for those that have it, and it has also broken the client's web frontend.

SAGoons is ranked 69, but lacks a logo: https://stats.foldingathome.org/team/150

Old page: https://statsclassic.foldingathome.org/team/150

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Vir
Dec 14, 2007

Does it tickle when your Body Thetans flap their wings, eh Beatrice?


F@H has rolled back the new stats pages, because it broke the web client. This premature rollout also revealed that many third party websites were hammering the statistics API with excessive calls. F@H has only one programmer on staff, which I guess is a typical symptom of how research grants pay for PhD projects, but infrastructure and support functions are under-funded.

Here's the beta page: https://statsbeta.foldingathome.org/team/150

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