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Korean Boomhauer
Sep 4, 2008

Korean Boomhauer posted:

how long until everything is Rust but irl

im already naked so

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MysteriousStranger
Mar 3, 2016
My "vacation" is a euphemism for war tourism in Ukraine for some "bloody work" to escape my boring techie job and family.

Ask me about my warcrimes.

upgunned shitpost posted:

I could see tromp straight up robbing people like bezos or zuckerberg.

who knows who's gonna be 'rich' at the end of this

donald trump and the republicans are going to implement ubi, m4a, and nationalize amazon and the cell carriers/isps by the end of this and mandate free disney+ netflix

Solarin
Nov 15, 2007

nationalize apple and give their fuckin hoarded wealth to me

Yuli Ban
Nov 22, 2016

Bot
Poison Control is begging people to stop drinking bleach

space uncle
Sep 17, 2006

"I don’t care if Biden beats Trump. I’m not offloading responsibility. If enough people feel similar to me, such as the large population of Muslim people in Dearborn, Michigan. Then he won’t"


Bean crew - can’t we rename to the legume choom gang? Must we exclude our lentil and black eyed pea brethren?

fits my needs
Jan 1, 2011

Grimey Drawer

MysteriousStranger posted:

donald trump and the republicans are going to implement ubi, m4a, and nationalize amazon and the cell carriers/isps by the end of this and mandate free disney+ netflix

nobama netflix

Zisky
May 6, 2003

PM me and I will show you my tits

Normal country.

Finicums Wake
Mar 13, 2017
Probation
Can't post for 8 years!

MysteriousStranger posted:

basement dwelling neackbeared incels are going to take over the earth?

the NEETs shall inherit the earth

Tythas
Oct 3, 2013

Never felt at home in reality
Always hiding behind avatars


Can i get both the Coronavirus and Super spreader tags I had an idiot who was supposed to be under quarantine come into our office and interact with me and then as they were leaving only then mention they were under quarantine

Gringostar
Nov 12, 2016
Morbid Hound

darwin in full effect

Leroy Diplowski
Aug 25, 2005

The Candyman Can :science:

Visit My Candy Shop

And SA Mart Thread
I just went to the dispensary to stock up for the long haul and my bill was $420. :2bong:

Solarin
Nov 15, 2007

Tythas posted:

Can i get both the Coronavirus and Super spreader tags I had an idiot who was supposed to be under quarantine come into our office and interact with me and then as they were leaving only then mention they were under quarantine

it's called a roaming quarantine

UnknownTarget
Sep 5, 2019

Mummy Xzibit posted:

Normal country.

Anyone rember that Qanon post on Twitter telling people to do exactly this?

magiccarpet
Jan 3, 2005




Leroy Diplowski posted:

I just went to the dispensary to stock up for the long haul and my bill was $420. :2bong:

Did some sort of Bell or kazoo go off

Admiral Ray
May 17, 2014

Proud Musk and Dogecoin fanboy

big government commies trying to tell me what to do!!!!

Leroy Diplowski
Aug 25, 2005

The Candyman Can :science:

Visit My Candy Shop

And SA Mart Thread

magiccarpet posted:

Did some sort of Bell or kazoo go off

No, but me and the weed girl both said "nice" at the same time

Foo Diddley
Oct 29, 2011

cat

https://www.youtube.com/watch?v=Sumb3GYuAT8

Thesaurus
Oct 3, 2004



It's real. As I posted the other night, my friend in the ER had to intubate a woman after bleach perforated her esophagus, this using up a ventilator in the process

Delthalaz
Mar 5, 2003






Slippery Tilde

Vox Nihili
May 28, 2008

Korean Boomhauer posted:

how long until everything is Rust but irl

Be the change you want to see

Mayor Dave
Feb 20, 2009

Bernie the Snow Clown

Tythas posted:

Can i get both the Coronavirus and Super spreader tags I had an idiot who was supposed to be under quarantine come into our office and interact with me and then as they were leaving only then mention they were under quarantine

haha

lmao

OWNED

Bearjew
Apr 18, 2017



Mayor Dave posted:

haha

lmao

OWNED

Fuck You And Diebold
Sep 15, 2004

by Athanatos
99 bottles of bleach on the wall, take one down pass it around, 98 bottles of bleach on the wall

D1E
Nov 25, 2001


I mean... things are really loving terrible.

LMAO.

Korean Boomhauer
Sep 4, 2008
getting owned owns

Goreban Dallas 2.0
Jan 4, 2019


https://twitter.com/sarahkliff/status/1240026660872900613?s=21

this is fun

Vox Nihili
May 28, 2008

Leroy Diplowski posted:

I just went to the dispensary to stock up for the long haul and my bill was $420. :2bong:

That's a lotta weed

Vox Nihili
May 28, 2008
The economy is saved

Rah!
Feb 21, 2006


its rush hour, but the freeway traffic is like midnight traffic :skeltal:

Woodchip
Mar 28, 2010
Nevada just shut down nonessential businesses and casinos.

https://www.rgj.com/story/news/2020/03/17/breaking-sisolak-announce-statewide-shutdown-nonessential-businesses/5074640002/

Chris James 2
Aug 9, 2012



For 30 days

turd in my singlet
Jul 5, 2008

DO ALL DA WORK

WIT YA NECK

*heavy metal music playing*
Nap Ghost

Utz posted:

quarantine is a good time to help each other out and pay it forward. so grab all of your roommates’ cast iron pans and give them a good bash inna head - you’ll feel good for surprising them with a good deed and they’ll thank you!

got one roommate that needs a good deed

last night he was trying to get our other roommates to go out to dinner with his girlfriends family

"cmon dont be a pussy lets go get some corona!"

Victory Position
Mar 16, 2004


Zokari
Jul 23, 2007


read that as nonessential casinos and was very hyped

turd in my singlet
Jul 5, 2008

DO ALL DA WORK

WIT YA NECK

*heavy metal music playing*
Nap Ghost

D1E posted:

I mean... things are really loving terrible.

LMAO.

Mirthless
Mar 27, 2011

by the sex ghost

Thesaurus posted:

It's real. As I posted the other night, my friend in the ER had to intubate a woman after bleach perforated her esophagus, this using up a ventilator in the process

this lady is pretty much guaranteed to die if she gets the virus now right???

i cannot imagine a worse time to open your breathing parts to infection in such a spectacular way than right now

Inceltown
Aug 6, 2019



jimmyjams
Jan 10, 2001


King Kong of Megadongs
Gobblin' them mega schlongs
Makin' sure they mega long
Stroke' 'em if they mega strong

Zeriel posted:

I almost certainly had a job lined up at the start of last week. Today there's not much of a chance that will happen.
I can't draw unemployment because I quit my last job thinking I had a new one ready to go.
Due to a loving global pandemic and sudden economic collapse.

Nothing seems real anymore.

old post, but if you have proof of the offer like an official offer letter or something, you might want to try filing anyway. if you have that kind of proof you might be able to make a good case that your situation counts as a layoff instead of a "quit"

jimmyjams fucked around with this message at 03:26 on Mar 18, 2020

twoday
May 4, 2005



C-SPAM Times best-selling author


*cracks knuckles*

it's time for some

BCG Theory

Part 2: History and Recent Events


A couple of people were asking me about my previous post related to the theory that BCG vaccine may be protective (or not) against coronavirus. It's been a while since that post and I've been thinking some more about this, as well as doing some research, so I thought I would give an update on my latest findings and observations.

First of all, two relevant articles that previously eluded my attention.

1. An analysis of the current Coronavirus epidemic (Covid-19) written by Dr. Megan Murray MD, MPH, ScD, who is the Harvard Medical School Global Health Research Core Director and the Ronda Stryker and William Johnston Professor of Global Health at the Department of Global Health and Social Medicine.

quote:

Can anything be done in the meantime in terms of vaccination?

Some vaccines have been shown in previous studies to have non-specific effects, meaning that they lower the risk of infection or disease due to infectious agents that are not specifically targeted by the vaccine. One of these is BCG, a live attenuated vaccine specific for tuberculosis. This vaccine is given at birth and is the most widely distributed vaccine in the world with almost all countries mandating its use with the exceptions of the Netherlands and the US, where TB rates are extremely low. We and others have shown that the efficacy of neonatal BCG against tuberculosis wanes with age (which may be a proxy for time since vaccination) (1,2).

Remarkably, in addition to its effect on TB, BCG has been shown to reduce the occurrence and severity of a range of other unrelated infectious diseases. Both observational studies and randomized controlled trials suggest that BCG vaccination can halve the risk of childhood death in countries with high rates of under-5 mortality (3,4). Notably, the mortality from TB in children in these areas was not high enough for a decline in TB incidence to explain this result; common causes of early childhood mortality in these settings were diarrheal and acute respiratory infections. Other studies found that BCG-vaccinated individuals experience lower rates of acute lower respiratory tract infections among many types of other infections (5,6). Interestingly, a decline in respiratory infection was observed in several randomized clinical trials in adults, including one conducted in individuals 60-75 years of age (7,8). These non-specific effects of BCG have also been shown in animal challenge models for a range of different pathogens (reviewed in 9-11) as well as in human challenge studies for malaria (12) and an attenuated yellow fever virus (13).

Revaccination with BCG has shown to be safe and immunogenic. In a recent clinical trial of re-vaccination of adolescents in South Africa, the BCG re-vaccinated group experienced a reduction in the rate of TB infection compared to people vaccinated only once as well as a three-fold reduction in upper respiratory infections compared to those who received either a placebo. Given that BCG vaccine is widely available, and that vaccination/revaccination is safe, cheap, and immunogenic, we feel that it will be important to explore its possible efficacy in this epidemic. The safety of the BCG in the setting of Covid-19 disease could be rapidly explored through infection in an animal model and unlike other more specific vaccines which will require phase one and two testing, a phase three clinical trial of vaccination/revaccination with BCG could begin promptly. We currently believe this should involve a first BCG vaccination in health care workers who are likely to be exposed to Covid-19 in the US and revaccination of similarly exposed health care workers in countries where BCG is used at birth.

This is pretty much what I said in my last post. Sounds a little less crazy when a higher-up from Harvard says it, doesn't it?

2. Researchers from Spain have learned that receiving the bacille Calmette-Guérin vaccine at birth may confer heterologous protection against hospitalization for respiratory infections and sepsis.

quote:

“Although we did not find a significant effect on child mortality, the study suggests that BCG vaccine may have significant beneficial effects on the health of pediatric patients from a developed country,” the researchers wrote in Clinical Infectious Diseases. “Additional research is needed to define the path toward obtaining unequivocal evidence on these issues that would support future robust, evidence-based adjustments in immunization policies.”

The researchers, from the translational pediatrics and infectious diseases section of Hospital Clínico Universitario de Santiago de Compostela in Spain, conducted a retrospective epidemiological and hospital-based surveillance study that covered 1997 to 2011. BCG was part of the immunization program in Spain until 1982 and administered to every newborn. Since then, however, only the Basque Country region continued to administer the vaccine. The researchers identified children aged younger than 15 years admitted for upper or lower respiratory infection, sepsis not related to tuberculosis and TB disease. They then evaluated the relationship between the hospitalization rates for the diseases and the geographic location the patient was born to control for influences other than BCG vaccination.

There were 464,611 hospitalizations during the time period. In Basque Country, the hospitalization rate related to respiratory infections not attributable to TB was lower compared with the rest of Spain, a total preventive fraction of 41.4%. (:snoo:) The hospitalization rate was significantly decreased for all age groups in Basque Country.(!!!) The hospital rates for sepsis not attributable to TB also were significantly lower in Basque Country, compared with the rest of Spain, a total preventive fraction of 35.7%.

From the original study:

quote:

CONCLUSIONS:
BCG vaccination at birth may decrease hospitalization due to respiratory infections and sepsis not related to tuberculosis
through heterologous protection.

But Spain has the highest growing death rate in Europe right now, so doesn't this prove that it's ineffective? No. Allow me to explain.

History of BCG Vaccination

As I have been trying to research which variant of the vaccine was used in which countries I have faced many stumbling blocks. Often I find contradictory things written in articles. For instance, some articles will say that India uses the BCG-Moscow strain, while others say that they use the BCG-Denmark strain. This is partially due to political reasons, and partially due to the market and issues of supply and demand. Nowadays in the global economy it's much easier to ship vaccines in large quantities around the world, and it seems that most health policies focus on inoculating people with any version of the BCG vaccine, and they treat the different strains interchangeably. So it turns out that in India they use both variants, because at times supplies of one were short and they had to use the other. Other times it’s more of a political issue, or one of scarcity. In both north and south Korea, for instance, they used the Japanese strain until the late 1950's, at which point South Korea switched to a local variant derived from BCG-Denmark, to be more in line with the vaccination schedule of the Western world.

But if we are looking at the relationship between this vaccine and COVID-19, we have to examine the history of this vaccine a bit more closely. Obviously the most vulnerable group is the elderly, and if they were vaccinated at all this likely took place 60 or 80 years ago. Back then the world was very different. At the height of the Cold War, the world was divided in two, and so was the availability of vaccines. Over the years different countries have had different policies, and different strains of BCG available to them. Especially in western Europe, policies have changed quite a few times.


Spain

Let's take a look at Spain:



Their death rate is soaring. But they didn't always have a universal vaccination policy, only for 16 years between 1965 and and 1981, meaning only people who are currently between age 39 and 55 got the vaccine. But in that study I quoted above it mentioned that vaccination was continued in the Basque country for later on and reduced the rate of respiratory illnesses there among all age groups. Let's see if we can see this on a map.

Here is a map of the cases in Spain as of today:



Madrid has the highest case rate. The Basque country is the little bit in the upper right with 765 cases and the surrounding area. Seems pretty high too! But you have to keep in mind population density.



It's also one of the densest parts of Spain. Here I calculate the rate of infections:

Madrid - 4871/6,661,949 = 0.0731%
Biscay - 765/1,149,628 = 0.0665%

So the rate in the Basque country is indeed somewhat lower. But if we look at Catalonia, the rate of infection is significantly lower:

1394/7,522,596 = 0.0185%

Why is that? Catalonia is a rather unique region within Spain, that has long had its own regional policies. They have a unique history in fighting TB as well, and were the second area to adopt widespread BCG vaccinations, after France, in 1926. I haven't been able to find sufficient data to say for sure, but it seems they had the infrastructure in place early on to carry out widespread BCG vaccinations even before the national mandatory vaccinations were adopted throughout Spain in 1965. It's really hard to dig this stuff up, especially in languages I don't speak, but it would be really interesting to see if the old people in Catalonia right now were given the vaccine as children or not.

To get back to the difference between the Basque country and Madrid, the main difference between those two regions is that one continued giving vaccines after the other stopped. The one that continued giving them has a lower rate of infection. That brings us to...

Herd Immunity

Let me be clear. Boris Johnson's proposal to give the UK population herd immunity to COVID-19 is insane, and would have practically amounted to genocide. However it seems that the statistics he was basing this plan on were using data from viral pneumonia, not COVID-19, and were grossly miscalculated, and he has now moved away from that policy. It has in the meantime been adopted in the Netherlands, where I sit now, waiting for death.

However, the idea of herd immunity itself is not insane. If significant portions of a population are immune to an illness (let's say 90%), then the disease will not be able to get a firm foothold in most people, the virus will not reproduce and spread as quickly, and even when it does spread it is more likely to "fizzle out" rather than causing an outbreak. This leads to lower rates of infection and mortality. So, perhaps, one reason that the rate of infection is lower in the Basque country than in Madrid is because more young people have the BCG vaccine, and as stated in the study mentioned above, therefore also have lower rates of respiratory infections, and are therefore spreading the illness to a lesser degree to the old people around them. Perhaps! Unclear! More data is required!

East Block Data

As I mentioned in my original post, one interesting feature is the lack of infection in certain countries in Eastern Europe. Here is the most recent map I could find:



Compare it to a map of socialist countries during the Cold War:



Now in Central Asia:



Soviet member states:



And finally (and most damningly), Germany:





So, does socialism prevent the spread of coronavirus? All signs point to yes. But not just in the present, also in the past. The BCG vaccination policy in the Soviet bloc was much more rigorous than in the west, and besides using the Moscow strain of BCG vaccine, it seems to have been (and still is) common practice in many of these countries to give the vaccine not only at birth, but also one or more times throughout the lives of the citizens there. Children would get a second injection of the vaccine at around age 7, and sometimes even later on in adulthood. If the BCG vaccine does indeed provide protection against respiratory infections, this would be one of the most protected populations on earth against COVID-19. If BCG provides resistance or immunity to COVID-19, then these countries would have tremendous levels of herd immunity, and the spread and severity of outbreaks there should be significantly limited. This does seem to be reflected in the data we have so far.

There are other explanations, such as the idea that these countries adopted stricter regulations for containment earlier on, or that they are all not testing adequately enough, or that they are simply lying. However, these ideas are especially questionable with regards to former Soviet Bloc countries that have since joined the EU. We will see soon enough whose hospitals are overflowing and whose aren't; that's a lot harder to cover up.

Besides this, I just wanted to make a note about Japan and South Korea, which both have low death rates compared to the west. I previously wrote some incorrect info about the situation in Korea. After some research, as I now understand it, Korea had a BCG-Tokyo vaccination program and then South Korea later switched to BCG-Denmark. As I mentioned in my previous posts, it seems likely that the strain of the BCG vaccine has an impact on the rates of mortality and transmission. The countries which have vaccines in the first cluster of historical BCG strains (BCG-Moscow and BCG-Tokyo) seem to have pretty low rates of mortality. In Japan, both the rates of transmission and mortality seem rather unexpectedly low compared to the global average. In Korea the rates of transmission are much higher, but the rate of mortality is still rather low. This could perhaps be explained by the fact that in Korea the older generation (65+), if they were vaccinated, had the BCG-Tokyo strain, and thus had more protection, while the younger generation had BCG-Denmark. Or by the fact that they test more. There are a lot of variables here.

Next time I will go further into that issue, and also investigate the situation in Mexico, Turkey, and elsewhere.

Once again - Italy, the Netherlands, and the US have never had mandatory universal BCG vaccinations, and not really Spain either. If this theory is true (and I'm still not sure that it is), we can expect there to be higher rates of transmission and death in those places than elsewhere. The rates for Spaniards between age 40 and 55 should be lower.

just saying!!!!!!!!!!!!!!

Update: since I posted this last night an interesting bit of news has come across the wires:

https://www.dutchnews.nl/news/2020/03/will-tb-vaccine-help-healthcare-workers-fight-corona-dutch-hospitals-experiment/

quote:

Will TB vaccine help healthcare workers fight corona? Dutch hospitals experiment

Nijmegen and Utrecht academic hospitals are to experiment with using a tuberculosis vaccine (BCG) to try to better protect hospital workers against coronavirus. The vaccine is known to stimulate the immune system and may lead to healthcare workers who do pick up the virus having milder symptoms, researchers say. The experiment, which has been approved by the medical ethics testing commission, involves giving 500 workers the vaccine and a further 500 a placebo. If the vaccine appears to have an effect, all healthcare workers given the option. ‘We are in the middle of the outbreak so we want the results as quickly as possible,’ said Marc Bonten, professor of molecular epidemiology at the UMC Utrecht.

Research has indicated that the vaccine stimulates immune systems to better fight off flu, but it is not known if there is a similar effect with coronavirus. ‘That is precisely the reason for this research,’ said Mihai Netea, professor of experimental medicine at Radboud’s medical centre. ‘If fewer people in the vaccinated group become ill, than that will be an encouraging result.’ While work is underway on developing a vaccine against coronavirus, experts say it will take months if not years before one has been identified and produced.

Edit 2: Here is a link to part 3

twoday fucked around with this message at 22:49 on Mar 25, 2020

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Admiral Ray
May 17, 2014

Proud Musk and Dogecoin fanboy

Thesaurus posted:

It's real. As I posted the other night, my friend in the ER had to intubate a woman after bleach perforated her esophagus, this using up a ventilator in the process

how much bleach did she drink?

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