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Rauros
Aug 25, 2004

wanna go grub thumping?

Pittsburgh Fentanyl Cloud posted:

It's West Virginia, there are no growth industries there besides vice.

The two nicest buildings in that area are the casino and a strip club

The only other thing they have is waiting to die

after trail running in tomlinson run, i took my ex along the strip of the ohio river from east liverpool to shippingport, and he didn't believe america could look like that.

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Rauros
Aug 25, 2004

wanna go grub thumping?

facetoucher cat posted:

I'm wondering if part of the reason Georgia coronavirus rates haven't spiked is because people here are outside often and do outdoor activities this time of year or just recently in the past?

i've lived many places and georgia is one of the least outdoorsy places i've ever lived.

Rauros
Aug 25, 2004

wanna go grub thumping?

i think we have different definitions for outdoorsy. i meant outdoor recreation in public lands. once you get away from the looky-loo short distance waterfall hikes, there is nobody. everyone hides inside with their a/c in athens, so that's been my georgia experience. i visited a friend in gainesville before the lockdowns, and i was shocked by how many people were outside embracing the heat, and i was reminded what a normal college town should be like.

Rauros
Aug 25, 2004

wanna go grub thumping?

yeah, having the secret trails all to myself for running in athens has been a boon for my social distancing.

Rauros
Aug 25, 2004

wanna go grub thumping?

A Buttery Pastry posted:

What is going on with those confidence intervals? Hawaii is presumably because of practically no cases, is it the same for the others?



yeah, low cases will make the estimate of R0 worse.

Rauros
Aug 25, 2004

wanna go grub thumping?

Bip Roberts posted:

when the vaccine comes out they should get the dudes who shoot feral pigs from helicopters to tranq dart inoculate people

https://www.theonion.com/more-corporations-using-tag-and-release-programs-to-stu-1819576598

Rauros
Aug 25, 2004

wanna go grub thumping?

facetoucher cat posted:

Also the economy must be doing better because i had an interview today, booked another for tomorrow, and turned one down for a job I was hoping didn't contact me back. Kinda happy that I didn't get the other job once I realized it would be a Pentagon contract

Yeah, federal government must be working again. I just got rejected for a bunch of positions.

Rauros
Aug 25, 2004

wanna go grub thumping?

Ardennes posted:

There is a steroidal therapy out there that improves outcomes for people on respirators, it isn't a cure. I am sure the news is probably reporting it as much because everything is morally bankrupt.

lol, good ole dexamethasone

Rauros
Aug 25, 2004

wanna go grub thumping?

Radirot posted:

bunch of agoraphobics scared of going out

serve me food!

Rauros
Aug 25, 2004

wanna go grub thumping?

Radirot posted:

if the restaurant wasnt open i wouldnt care to complain but it was open and i figured it was safe enough in this area to do so after being in quarantine for 3 months. :shrug:

if you haven't noticed yet, no one is in charge. godspeed.

Rauros
Aug 25, 2004

wanna go grub thumping?

nooneofconsequence posted:

uh just quarantine for 2 weeks? not that hard!

i visited my parents, because we had been isolating the whole time. after 2 weeks of keeping our distance, i got hugs when i left and they felt really good.

Rauros has issued a correction as of 05:00 on Jun 18, 2020

Rauros
Aug 25, 2004

wanna go grub thumping?

empty whippet box posted:

this thread and posts like this keep me tethered to not freaking the gently caress out because I keep starting to gaslight myself about it, but no goddamnit, it is this insanely bad and everyone else really are the weird ones for not being as worried about it as me. just have to hold on until it gets undeniably bad again I guess

my coworkers invited me a couple days ago to go to a brewery tonight. i asked about distancing, and they said it was easy since you could go outside. i slept on it a couple nights, and today, i was like gently caress no. no one should be getting unnecessary service right now. get a growler if you want to support the business and meet in your backyard.

Rauros
Aug 25, 2004

wanna go grub thumping?

mod sassinator posted:

in animals they've only ever made one for FIV, and apparently that has a horrible track record

FIP :science:

Rauros
Aug 25, 2004

wanna go grub thumping?

antibodies may decline, but no one knows what the adaptive memory response or lack of one looks like yet

Rauros
Aug 25, 2004

wanna go grub thumping?

oxsnard posted:

isn't it much more likely that this becomes like a cold in that people will get infected regularly but because everyone is exposed to it at an early age it affects you less when you get subsequent infections throughout your life

you get a cold repeatedly, because there are like 200 cold viruses.

Rauros
Aug 25, 2004

wanna go grub thumping?

Raccooon posted:

Have we ever seen a disease that re-infected people 3 months later after having it? Has this ever happened? Mainly asking because the fear of that for this one seems like paranoia.

foot-and-mouth disease virus in ungulates escapes immunity and vaccines, because it mutates rapidly. coronaviruses are relatively stable.

Rauros
Aug 25, 2004

wanna go grub thumping?

Raccooon posted:

So I take that as the idea of having a COVID-19 re-infecting frequently is unlikely. Is that right?

unprecedented might be the word. biology doesn't have a rule book.

Rauros
Aug 25, 2004

wanna go grub thumping?

Admiral Ray posted:

yeah it does, it's called Molecular Biology of THE CELL 6th Edition

you can describe molecular interactions, but in the context of the red queen hypothesis, things get murky.

Rauros
Aug 25, 2004

wanna go grub thumping?

Munin posted:

I thought that there was a FMD vaccine and that the decision not to use it was an economic one?

Namely, that the FMD vaccine (obviously) messes with and serological testing for actual infections. That means a country can no longer be certified as FMD free, which impacts live cattle exports.

in developed countries, yes, but africa is a mess due to african buffalo being a natural reservoir host. i did work in south africa where they have an fmd endemic zone while most of the country is fmd free. they have to vaccinate cattle every 3 - 6 months on the outside of kruger national park, because buffalo occasionally break through the park fence.

Rauros
Aug 25, 2004

wanna go grub thumping?


rad, i saw this at a virtual trail running film festival and was waiting for it to be posted!

Rauros
Aug 25, 2004

wanna go grub thumping?

COVID-420 posted:

TOP 5 NEW CASES USA

1. California +5,528 *NEW RECORD*
2. Texas +5,112 *NEW RECORD*
3. Florida +2,926
4. Arizona +2,196
5. Mississippi +1,265


yikes, monday is usually the weekly nadir

Rauros
Aug 25, 2004

wanna go grub thumping?

Zeriel posted:

They also say the Tcell response lasted for at least 69 days[nice].

Entering the uncharted waters of immunology. Activated memory T cells only live 6 months, and it's currently a mystery how they maintain lifelong immunity. One hypothesis is that they recruit naive memory T cells to keep the pathogen memory going.

Rauros
Aug 25, 2004

wanna go grub thumping?

i felt like a crazy person putting a discarded covid public health sign back up at a bus stop on my run today

Rauros
Aug 25, 2004

wanna go grub thumping?

i tried to get permission to go shelter with a friend in another state while i'm off duty at work and have no reason to go into the building for the next 5 weeks and will be working from home the whole time. they said no, because the university is officially back open on july 1st while my state is posting record case numbers :shepicide:

Rauros
Aug 25, 2004

wanna go grub thumping?

Thesaurus posted:

Just do it and don't tell them if you're not going to be in anyways?

yeah, that would have been the better plan. i laughed today, when i reached across to the sharps container and my hand hit a 3 foot tall clear plastic divider that was recently installed between the microscopes. open 'er up!

Rauros
Aug 25, 2004

wanna go grub thumping?

this is interesting. american media is saying covid toes not likely covid, because antigen tests are negative, and then this spanish paper comes out the same day:

https://www.aa.com.tr/en/europe/spanish-researchers-isolate-coronavirus-in-covid-toes/1890247

Spanish researchers isolate coronavirus in 'COVID toes'
Scientists detect virus on swollen toes of pediatric patients who tested negative for disease


"In this study, all seven patients, aged 11-17, whose skin was analyzed, tested negative for COVID-19 in a PCR test. The researchers later detected viral particles within the inner layer of the blood vessels found in their skin samples."

My toe is still pink 3 months later...not normal.

Rauros
Aug 25, 2004

wanna go grub thumping?

mastershakeman posted:

How could this even be possible , it just chilled out for 9 months in 2019?

Sounds like contamination. Why wouldn't it show up later than March if they tested until December? Can't draw any conclusions from one positive sample.

"These results encouraged the researchers to analyse some frozen samples between January 2018 and December 2019, with the shocking results of the presence of SARS-CoV-2 genome in March 2019, before any notification of COVID-19 cases in the world. “All samples were negatives regarding the SARS-CoV-2 genome presence except for March 12, 2019, in which the levels of SARS-CoV-2 were low but were positive, using two different targets”, says the researcher."

Rauros has issued a correction as of 15:35 on Jun 26, 2020

Rauros
Aug 25, 2004

wanna go grub thumping?

Bruce Hussein Daddy posted:

Athens, officially Athens–Clarke County, is a consolidated city–county and college town in the U.S. state of Georgia. Athens lies about 70 miles (110 kilometers) northeast of downtown Atlanta. The University of Georgia, the state's flagship public university and an R1 research institution, is in Athens and contributed to its initial growth. As of 2019, the U.S. Census Bureau's estimated population of the consolidated city-county (all of Clarke County except Winterville and a portion of Bogart) was 126,913;

woot, my present purgatory

Rauros
Aug 25, 2004

wanna go grub thumping?

Vishass posted:

Anecdotally, I think GA is going to pop off soon. I mean the graph sure suggests that but I've heard from multiple sources it is getting very hard to get a test in Atlanta. Like the line is hours long. Testing is open until 7 but if you aren't in line by 3pm you're sent home. Heard from multiple people they waited for over an hour and gave up and have been trying to get tested for days

secured a roadtrip out for 2 weeks. i hope borders don't close before next weekend.

Rauros
Aug 25, 2004

wanna go grub thumping?

Nocturtle posted:

The comment on lost cognitive function reminded me of this fun article:


Thanks for posting this. I had the tingling sensations (arcoparasthesia) when I had my covid toe back in March, and hadn't seen that symptom confirmed yet.

Rauros
Aug 25, 2004

wanna go grub thumping?

FizFashizzle posted:

this is a very click baitey article.

Type 2 pneumocytes (the ones infected in the lung) will reach out to other cells and borrow stuff if they need it. Like if they're short a potassium or whatever they'll reach out and take some from another nearby cell. It's really important for this to happen because lung tissue doesn't really regenerate and once those surfactant producing cells are gone they're gone (stop smoking).

cells talk to each other all over the body. cell to cell interaction are absolutely fascinating and we're just scratching the surface of how they communicate. in this case, a dying type 2 cell is reaching out to try to get whatever it needs that the virus is destroying/not allowing to be made. as the virus takes over the cells productive capacity the other things required to live are not working.

it's just now when that little cell reaches out to stave off apoptosis, it's hand is covered in virus and it's transmitting. they've known this for a while, but now it's cool they have a picture of it.

so yeah think of it as a dying cell reaching out to a friend for help and infecting his friend in the process.

thanks for the bucket of ice water. i somehow missed this in my disease ecology education. other viruses commonly do this:

"Viruses, including Marburg and Ebola, have been found to hijack filopodia, forcing them to grow longer, branch, and ferry virus particles into their neighbors. The mechanism is especially well-studied in another virus called vaccinia, she notes, where research has suggested it plays a role in “superspreading” the virus from one cell to others."

https://www.wired.com/story/old-dru...wKfcvk7OoiAZgp8

Rauros
Aug 25, 2004

wanna go grub thumping?

The Alpha Centauri posted:

jfc its just a mask

don't people get all horny about heart-throb surgeons wearing masks on tv dramas

Rauros
Aug 25, 2004

wanna go grub thumping?

PerniciousKnid posted:

I need a whole season of Cells At Work to explain this to me.

TLDR: IP10 is normally a transient chemical signal that tells T cells to get to work. With covid, the IP10 signal doesn't turn off, and the T cells burn themselves out and die, and deplete an arm of adaptive (learned) immunity which is bad for the whole immune response. Suppressing a cytokine storm by blocking IL-6 doesn't work with covid, because it also dampens the normal immune response. Children are pumping out new T cells from their still active thymus, so that might be a resistance trait for them. Since the covid immune response is tangled web of contradictions, maybe targeting the virus itself with antiviral medication might be the way to go.

Rauros
Aug 25, 2004

wanna go grub thumping?

TheLemonOfIchabod posted:

can we expect antivirals to take less time to develop than the 20-30 years it took for HIV

i think the short course of this disease is going to make antivirals a hard sell for big pharma. hiv users have to stay on them for life, while severe covid disease is a few weeks, because there is no latency.

Rauros
Aug 25, 2004

wanna go grub thumping?

TheLemonOfIchabod posted:

I think you’re right regarding the demand/perception, but did that article you posted not suggest at least the possibility that longer term immunodeficiencies develop from this?

i read the article as it was only a short term depletion while the body was still fighting the virus. once it's cleared, i'd hope the immune response would return to baseline. HIV is fun, because it's like a microcosm of evolution where the virus mutates in the host to exploit CD4+ T cells later and that's when AIDS happens.

Rauros
Aug 25, 2004

wanna go grub thumping?

SpaceCadetBob posted:

This is actually really well done.

I'm sure it wouldn't persuade a single chud, but I'm gonna pass it around to help make fence sitters a bit more resistant to chud garbage.

the one i see a lot are people doing physical activity, and it's harder to breathe. that's because ventilation volume can increase up to 20 times during intense exercise and a mask does restrict some of that greatly increased air flow. your heart rate will go up and it might feel harder to breathe, but you can still function (normal SPO2), and it will even strengthen your respiratory system. however, most chuds bitching about masks aren't doing anything to require that much ventilation.

Rauros has issued a correction as of 22:52 on Jun 28, 2020

Rauros
Aug 25, 2004

wanna go grub thumping?

pshhh...you guys throwing around that 20 million number...and the "experts" agree!

https://apnews.com/9d742ebaf97612860438dd3890dc810e



only 6% of the population so far is very bad.

Rauros
Aug 25, 2004

wanna go grub thumping?

Atrocious Joe posted:

i know there has been virus DNA found in human and other animal genomes. Can the virus that causes Covid maybe do that? Is that how we become one with the virus

approximately 5% of our dna are junk sequences from endogenous retroviruses. coronaviruses don't do that though.

Rauros
Aug 25, 2004

wanna go grub thumping?

brugroffil posted:

I get that I'm older now and going out to bars hasn't appealed to me in years, but what the gently caress is wrong with everyone.

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Rauros
Aug 25, 2004

wanna go grub thumping?

mod sassinator posted:

This is looking up 'misery hill' at ~13k feet on mt. shasta last year--it looks like the top is right there... just another big push to go, let's see what's up there..


lol nope, you got another 700 or so vertical feet to go bitch!


(it's worth it to reach the top though)


we are currently in the 'misery hill' part of this pandemic climb, have fun

i miss those loving volcanoes so much

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