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Hexyflexy posted:Happy easter - it'll get you drunk and is also a bomb! Is this a thing that exists, as in someone put it into a paper? Asking for a friend.
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Apr 2, 2018 06:32
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iospace posted:Is this a thing that exists, as in someone put it into a paper? I don't think so. This is just what happens when drunk goons discover molecule structure drawing tools.
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Apr 2, 2018 09:14
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iospace posted:Is this a thing that exists, as in someone put it into a paper? IANAC, but for comparison, the descriptors in my previous post were all for compounds with 3 nitrogens in a row (Ooh, I missed this azideism: "- Various devastating explosions were reported while reaction mixtures were being concentrated). Tetrazine has 4, and is used to make contact explosives more sensitive. So 25 in a row... ps. I just learned a new word.. explosophore!
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Apr 2, 2018 14:13
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Apparently "tetrazine" is also the name of some totally unrelated bullshit diet supplement. Dietpillsworld.com (a great domain name) says "If you are contemplating on trying Tetrazene, have a discussion with your physician first and do not incorrectly purchase the explosive component." which is a good premise for a cautionary tale. Speaking of ideas for cautionary tales, I can't access the paper but the reference stub for Is Hexazine Stable? is almost a work of art in itself. The rhetorical-sounding question, big asterisk, dedication, lack of abstract... if you put "(May 13, 1921 – May 13, 1981)" after Professor Heilbronner's name it would be a research chemistry equivalent of "Baby Shoes".
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Apr 2, 2018 14:34
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Chillbro Baggins posted:Is that the indicator that is also the least bad denaturant for ethanol? Phenolpthalein is the one that gives you the screaming liquid shits if you ingest it, I thought that was the joke he was making.
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Apr 2, 2018 14:46
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Syd Midnight posted:Apparently "tetrazine" is also the name of some totally unrelated bullshit diet supplement. Invite your foes over for a hearty meal of chicken tetrazine
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Apr 3, 2018 00:17
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Phanatic posted:Phenolpthalein is the one that gives you the screaming liquid shits if you ingest it, I thought that was the joke he was making. Phenolpthalein was Ex-Lax until they changed the formulation, so yeah. However, a good thing to put in drinks is Methylene Blue. In acidic mixtures (most mixed alcoholic beverages) it's clear. In basic solutions (like urine) it's vibrant blue. It's also removed from the blood by the kidneys unchanged. Depending on hydration level, you can have someone pissing near-fluorescent green.
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Apr 3, 2018 00:24
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babyeatingpsychopath posted:Phenolpthalein was Ex-Lax until they changed the formulation, so yeah. It's also completely safe. No side effects other than pissing, making GBS threads and sweating blue or green.
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Apr 3, 2018 01:32
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Intoluene posted:It's also completely safe. No side effects other than pissing, making GBS threads and sweating blue or green. Reminds of an old frat party trick of putting bromthymol blue in someone's drink when they weren't looking. It had no effect other than turning the guy's piss bright green.
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Apr 3, 2018 01:34
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The dye in some brands of licorice jelly beans turns your poo poo green if you eat enough of them.
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Apr 3, 2018 02:13
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Since I was a wee goonling of ten years, my birthday cake has been a tie dyed one. Split white batter into five parts, dye each a different color, plop random blobs into the pans and give a quick swirl. Enjoy.* *And enjoy the green poop the following day.
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Apr 3, 2018 02:52
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PYF Dangerous Chemistry: Beets
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Apr 3, 2018 03:03
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Please don't put laboratory chemicals in people's food. It's probably most certainly totally safe but there's still a chance something nasty snuck in somewhere between production and dude's coffee. Ok PSA mode over. Making pee different colors is funny poo poo.
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Apr 3, 2018 03:38
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Hey I'm doing some research on a ~molecule of interest~ for my senior independent research requirement and here's a molecule you may be interested to know: This is resiniferatoxin or RTX. It's produced in a family of cacti, and is not to be confused with the RTX family of bacterial toxins which are large proteins not small organic molecules. This is the most potent TRPV1 agonist known. TRPV1 is a sensory protein present in a few types of neuron in the body but it's mostly known as a heat and pain sensor in peripheral neurons. Capsaicin is probably the most well-known TRPV1 agonist followed by vanillin. The selectivity of these agonists gives them some interesting uses beyond causing pain. Anyway, the aromatic head group on the right is what does the business of opening the calcium channel in the sensory neuron protein it targets. But the big polycyclic group on the left is what makes it 500 times more potent than capsaicin. Capsaicinoids bind to a nonpolar cavity in the protein's structure with their aliphatic tail. RTX does not have an aliphatic tail so much as a big squishy pile of nonpolar rings, which fit tightly into the nonpolar cavity and stick in there real good. At relatively low doses this obviously sucks to run into, but in very small doses it can actually desensitize the TRPV1-bearing neurons without firing the neurons, so it can be used as an analgesic. In higher doses it will kill these neurons so it's an interesting option for alleviating long-term neuropathic pain. For example if you inject it into a burning/stinging joint it will selectively kill only the neurons that carry the TRPV1 protein so motor neurons are unaffected. Of course you guys are probably interested in hearing about this because getting it in your eyes/mucous membranes is gonna give you a horrible experience. It's doesn't permeate membranes as easily as capsaicin though. Don't put this in people's food either. TRPV1 antagonists exist but they can't be administered internally because TRPV1 is involved in thermoregulation in the brain stem.
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Apr 3, 2018 04:03
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Phanatic posted:Phenolpthalein is the one that gives you the screaming liquid shits if you ingest it, I thought that was the joke he was making. We were making the same joke from dirrefernt ends, as it were. As my Chem 101 teaher explained, phenylpthalien is the non-gentle laxative that modern gentle laxatives compare themselves to.
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Apr 3, 2018 04:14
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Bad Angus! Bad!
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Magnesium Citrate is the laxative all gentle laxatives should compare themselves to. About once a year I have to take it, and all I remember from the experiences are flashes of light, the crack of a gunshot, and the sound of breaking porcelain falling on a tile floor. I wake up three days later, a new man, fit and lean, with a shock of grey hair.
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Apr 3, 2018 04:18
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Metal Geir Skogul posted:Magnesium Citrate is the laxative all gentle laxatives should compare themselves to. Eat some veggies every now and then.
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Apr 3, 2018 04:20
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That's not the issue. It's for other medical stuff.
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Apr 3, 2018 04:21
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Mustached Demon posted:Eat some veggies every now and then. Veggies are what food eats. 
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Apr 3, 2018 04:54
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Metal Geir Skogul posted:That's not the issue. It's for other medical stuff. Ah I was thinking you poop annually with a massive, toilet-punishing blast worthy of the most OHNO compounds.
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Apr 3, 2018 04:56
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Like the guy in the Yoshi's Island 2 ad (warning, NSFL), yes. Also wait Paul Rudd was in a SNES ad? What? (saw in related videos on the side)
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Apr 3, 2018 05:01
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Metal Geir Skogul posted:Magnesium Citrate is the laxative all gentle laxatives should compare themselves to. Plus it's usually dirt cheap, but a little will go a long way, don't overdo (heh) if you can help it.
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Apr 3, 2018 05:35
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Metal Geir Skogul posted:Like the guy in the Yoshi's Island 2 ad (warning, NSFL), yes. Aw, Tony Jay. 
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Apr 3, 2018 06:37
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Intoluene posted:It's also completely safe. No side effects other than pissing, making GBS threads and sweating blue or green. It is bioactive, however, so you might lose your blue skin.
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Apr 3, 2018 08:29
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Arglebargle III posted:Hey I'm doing some research on a ~molecule of interest~ for my senior independent research requirement and here's a molecule you may be interested to know: So from time to time I've wondered about capsaicin creams as a remedy for pain. Is capsaicin up to something similar?
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Apr 3, 2018 14:23
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Yeah it can desensitize that particular nerve channel. Capsaicin taken internally is also a weight loss supplement because it desensitizes the body to hyperthermy to a small degree.
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Apr 3, 2018 14:48
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All I know is I love capsaicin to a probably unhealthy degree. Which totally isn't evidenced by the bottle of ghost pepper sauce in the kitchen. Nope, totally not.
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Apr 3, 2018 15:10
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iospace posted:All I know is I love capsaicin to a probably unhealthy degree. I highly recommend them if you're in a warm climate or you have a good indoor spot for them.
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Apr 3, 2018 15:55
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Nth Doctor posted:So from time to time I've wondered about capsaicin creams as a remedy for pain. Is capsaicin up to something similar? I have serious arthritis and every month go to the doctor to get local anesthetic injected, and then ridiculously high concentrations of capsaicin cream spread on my joints to stun the nerves (without the local I would be in agony until the numbing effect takes place).
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Apr 3, 2018 21:18
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Humbug Scoolbus posted:I have serious arthritis and every month go to the doctor to get local anesthetic injected, and then ridiculously high concentrations of capsaicin cream spread on my joints to stun the nerves (without the local I would be in agony until the numbing effect takes place). The moments when capsaicin cream pain kicks in and before the nerves get numb are really not great, I have to admit.
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Apr 3, 2018 21:54
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The last time I used a capsaicin patch for some neck pain it felt really good, right up until I realized I had literally burned a big chunk of my neck (not sure if it was a chemical burn or what but it wasn't fun).
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Apr 3, 2018 22:33
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I do know that back in the day (as in, 50-100 years ago), one home 'cure' for rheumatism was hitting the affected parts of the body with freshly picked stinging nettles. You see, the pain caused by rheumatism is so horrible that the pain caused by the nettles is preferable, and somehow the pain of the nettles overwhelmed the pain of the rheuma.
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Apr 3, 2018 22:47
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Carbon dioxide posted:I do know that back in the day (as in, 50-100 years ago), one home 'cure' for rheumatism was hitting the affected parts of the body with freshly picked stinging nettles. The Major Pain method of local anesthesia
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Apr 3, 2018 22:53
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I gave capsaicin a go for treating psoriasis. Oh boy did that not really help.
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Apr 3, 2018 23:06
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Carbon dioxide posted:I do know that back in the day (as in, 50-100 years ago), one home 'cure' for rheumatism was hitting the affected parts of the body with freshly picked stinging nettles. Still worked in tests in 2000: http://news.bbc.co.uk/2/hi/health/771563.stm
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Apr 4, 2018 00:52
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ulmont posted:The moments when capsaicin cream pain kicks in and before the nerves get numb are really not great, I have to admit. Tried making my own hot sauce once. Spent an hour finely mincing habaneros. Didn't wear gloves, but was careful not to rub my eyes. I expected the burning to become unbearable and force me to stop, but it didn't and at the end of it my hands weren't burning anymore, just... pleasantly tingly. Not precisely numb as much as warm and buzzy, like my hands were taking some awesome painkillers that only affected them. Weird feeling but kinda nice, it persisted even after I scrubbed them clean with soap, and I saw how capsaicin can have analgesic use. Then a half hour later I casually scratched my balls, and saw how capsaicin can also have comedic timing. Some chemicals love a good punchline.
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Apr 4, 2018 13:25
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Carbon dioxide posted:I do know that back in the day (as in, 50-100 years ago), one home 'cure' for rheumatism was hitting the affected parts of the body with freshly picked stinging nettles. Stinging nettles are interesting. To stop the pain, my grandpa taught me to take a nettle leaf and rub the area very aggressively. It pulls out the little hairs and the pain goes away. Either that, or it over-doses you on the poison and you stop feeling it. Either way, it works.
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Apr 4, 2018 14:21
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I have used nettles when I was out camping and my left hand completely felt like somebody was pounding on it with a sledgehammer. They do work.
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Apr 4, 2018 17:34
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Makes me wonder if it works the same way with the Gympie Gympie
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Apr 4, 2018 17:51
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Haha cool a potent neurotoxin that is also a chemo drug.
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Apr 4, 2018 18:01
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