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you realize that this makes you a little poo poo
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Oct 27, 2020 21:48
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naem posted:I’m job searching right now and wondering if I should just wait to see how bad this winter gets first Are you good with a shovel?
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Oct 27, 2020 21:48
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bob dobbs is dead posted:you realize that this makes you a little poo poo How so ?
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Oct 27, 2020 21:48
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Heh rules don't apply to me, I'm too smart and successful for coronavirus 
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Oct 27, 2020 21:50
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unpacked robinhood posted:My posh metropolitan neighborhood emptied in a few hours and I'm considering following suit. Is this the same thing as all the rich Italians using the days notice they received about impending lockdowns in the north to flee to the south and start spreading the virus around in places that previously didn’t have many cases?
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Oct 27, 2020 21:50
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I can isolate just as well in my parents vacant property. People figured selfish parisians leaving the capital were bringing the plague everywhere the first time and nothing happened either. I don't plan on doing any extra doorknob licking or public coughing once I'm there.
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Oct 27, 2020 22:00
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unpacked robinhood posted:I don't plan on doing any extra doorknob licking or public coughing once I'm there. You're missing out duder.
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Oct 27, 2020 22:11
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gay picnic defence posted:Is this the same thing as all the rich Italians using the days notice they received about impending lockdowns in the north to flee to the south and start spreading the virus around in places that previously didn’t have many cases? Hardly applies now. In all of Europe infection rates are between 'a lot' and 'oh wow'. There are no untouched villages to infect. If you have some rural property i don't see why you couldn't drive there and spend the lockdown there.
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Oct 27, 2020 22:21
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Colonel Cancer posted:Heh rules don't apply to me, I'm too smart and successful for coronavirus Thank you, Mr. President.
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Oct 27, 2020 22:23
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This winter is going to be loving miserable isn't it? 
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Oct 27, 2020 22:29
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Is there any science on whether interior cooling vs heating is worse for virus transmission indoors? Just curious if the grocery stores are safer or more dangerous in winter vs summer.
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Oct 27, 2020 23:03
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NihilismNow posted:Hardly applies now. In all of Europe infection rates are between 'a lot' and 'oh wow'. There are no untouched villages to infect.
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Oct 27, 2020 23:46
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NihilismNow posted:Hardly applies now. In all of Europe infection rates are between 'a lot' and 'oh wow'. There are no untouched villages to infect.  JOIN US
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Oct 27, 2020 23:54
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pro starcraft loser posted:This winter is going to be loving miserable isn't it? 
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Oct 28, 2020 00:12
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WaryWarren posted:You're missing out duder. Conveniently left out kissing every dude in a 10 meter radius as they galavant to their vacay stay away
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Oct 28, 2020 00:14
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Looks like we're at least a week out from the first efficacy readout on the Pfizer vaccine. I was hoping it would be this week, though it being after the election is probably much better in the long term.
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Oct 28, 2020 00:25
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pro starcraft loser posted:This winter is going to be loving miserable isn't it? What does absolute dread tell you?
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Oct 28, 2020 00:29
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HerStuddMuffin posted:I’d thank the Parisians to keep the plague they brought on themselves ?
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Oct 28, 2020 00:30
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I'm watching game 6 of the world series and it occurred to me that whichever one of these teams win there's most likely going to be a bunch of people flooding the streets to celebrate during a global pandemic.
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Oct 28, 2020 01:08
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explosivo posted:I'm watching game 6 of the world series and it occurred to me that whichever one of these teams win there's most likely going to be a bunch of people flooding the streets to celebrate during a global pandemic. A bunch of experts put out a report saying the Lakers winning a title likely caused the recent increase in Covid cases in LA, and thats without a parade and people being actively discouraged from gathering
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Oct 28, 2020 01:09
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Good news everyone. Some Covid Survivors Have Antibodies That Attack the Body, not Virus https://www.nytimes.com/2020/10/27/health/covid-antibodies-autoimmunity.html Some survivors of Covid-19 carry worrying signs that their immune system has turned on the body, reminiscent of potentially debilitating diseases like lupus and rheumatoid arthritis, a new study has found. At some point, the body’s defense system in these patients shifted into attacking itself, rather than the virus, the study suggests. The patients are producing molecules called “autoantibodies” that target genetic material from human cells, instead of from the virus. This misguided immune response may exacerbate severe Covid-19. It may also explain why so-called “long haulers” have lingering problems months after their initial illness has resolved and the virus is gone from their bodies. The findings carry important implications for treatment: Using existing tests that can detect autoantibodies, doctors could identify patients who might benefit from treatments used for lupus and rheumatoid arthritis. There is no cure for these diseases, but some treatments decrease the frequency and severity of flare-ups. “It’s possible that you could hit the appropriate patients harder with some of these more aggressive drugs and expect better outcomes,” said Matthew Woodruff, an immunologist at Emory University in Atlanta and lead author of the work. The results were reported Friday on the preprint server MedRxiv, and have not yet been published in a scientific journal. But other experts said the researchers who carried out the study are known for their careful, meticulous work, and that the findings are not unexpected because other viral illnesses also trigger autoantibodies. “I’m not surprised, but it’s interesting to see that it’s really happening,” said Akiko Iwasaki, an immunologist at Yale University. “It’s possible that even moderate to mild disease may induce this kind of antibody response.” For months it has been clear that the coronavirus can cause the immune system to run amok in some people, ultimately wreaking more damage to the body than the virus itself. (Dexamethasone, the steroid President Trump took after his Covid diagnosis, has proved effective in some people with severe Covid to tamp down this over-exuberant immune response.) Viral infections cause infected human cells to die. Sometimes the cells die a quiet death — but sometimes, and especially in the throes of severe infection, they can blow up, strewing their innards. When that happens, DNA, normally cloistered in coiled bundles inside the nucleus, is suddenly scattered and visible. In the typical response to a virus, cells known as B immune cells make antibodies that recognize pieces of viral RNA from the virus and lock onto them. But in conditions like lupus, some B cells never learn to do this and instead produce autoantibodies that glom onto DNA debris from dead human cells, mistaking them for intruders. Something similar may be happening in patients with Covid-19, the research suggests. “Anytime you have that combination of inflammation and cell death, there is the potential for autoimmune disease and autoantibodies, more importantly, to emerge,” said Marion Pepper, an immunologist at the University of Washington in Seattle. Dr. Woodruff and his colleagues reported earlier this month that some people with severe Covid-19 also have such unrefined B immune cells. The finding prompted them to explore whether those B cells make autoantibodies. In the new study, the researchers looked at 52 patients within the Emory health care system in Atlanta who were classified as having either severe or critical Covid-19, but who had no history of autoimmune disorders. They found autoantibodies that recognize DNA in nearly half of the patients. They also found antibodies against a protein called rheumatoid factor and others that help with blood clotting. Among the top half of the most seriously ill patients, more than 70 percent had autoantibodies against one of the targets tested, Dr. Woodruff said. “It’s not just that these patients have an autoimmune-like immune response,” he said. “It’s that those immune responses are coupled with actual true testable clinical auto-reactivities.” Some of the autoantibodies the researchers identified are associated with blood flow problems, noted Ann Marshak-Rothstein, an immunologist and lupus expert at the University of Massachusetts, Worcester. “It’s very possible that some of the coagulation issues that you see in Covid-19 patients are being driven by these kinds of immune complexes,” she said. If the autoantibodies do turn out to be long-lasting, she said, they may result in persistent, even lifelong, problems for Covid-19 survivors. “You never really cure lupus — they have flares, and they get better and they have flares again,” she said. “And that may have something to do with autoantibody memory.” Dr. Marshak-Rothstein, Dr. Iwasaki and dozens of other teams are closely studying the immune response to the coronavirus. Given the ease of testing for autoantibodies, it may soon become clear whether the antibodies were identified only because the researchers went looking for them, or whether they represent a more permanent alteration of the immune system. “It’s not clear to me what it all means at this point,” Dr. Pepper said. “It’s going to take a little bit of time to understand if this is something that’s going to lead to downstream pathology.” By good news I mean WEAR A MASK.
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Oct 28, 2020 01:38
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this is not incredibly special the body has like a half dozen learning systems. not just the mind, but metabolism, immunity, extracerebral neural poo poo, etc. all of them can get hosed up. after birth learning is a you pay a lot you get a lot sorta deal for a biological system e: ah they note it in the article too
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Oct 28, 2020 01:45
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What are the odds 2021 makes 2020 look like a walk in the park.
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Oct 28, 2020 04:39
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Philthy posted:What are the odds 2021 makes 2020 look like a walk in the park. 100%.
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Oct 28, 2020 04:42
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I guess Dr pepper was in fact a real doctor
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Oct 28, 2020 04:46
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Philthy posted:What are the odds 2021 makes 2020 look like a walk in the park. A walk in Yellowstone park when the supervolcano blows.
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Oct 28, 2020 04:57
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Colonel Cancer posted:Do some people really sit at home with 0 contact with outside world? What are you, a millionaire without a job? No Old
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Oct 28, 2020 05:23
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Philthy posted:What are the odds 2021 makes 2020 look like a walk in the park. Massive earthquake on the San Andreas. Economic collapse. War, possibly nuclear.
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Oct 28, 2020 05:25
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The San Andreas fault is weak. It’s a strike–slip fault, it can only store so much energy before letting go, and California is relatively well‐built for quakes now. The Great Cascade Quake or New New Madrid Quake are where it’s at.
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Oct 28, 2020 05:26
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Xenocides posted:A walk in Yellowstone park when the supervolcano blows. One can dream
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Oct 28, 2020 05:28
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The auto antibody big post right above the reason that is so ominous is because we can't do jack poo poo about autoimmune diseases. They're incurable and the medications for them are super expensive. God drat it
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Oct 28, 2020 05:29
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Spinz posted:The auto antibody big post right above the reason that is so ominous is because we can't do jack poo poo about autoimmune diseases. They're incurable and the medications for them are super expensive. God drat it well we cant let this virus run our lives !!! open 'er up!!
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Oct 28, 2020 05:31
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Is this immune response specific to covid or is this something that can happen with any immune response and this is just sensationalism?
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Oct 28, 2020 12:17
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Spinz posted:The auto antibody big post right above the reason that is so ominous is because we can't do jack poo poo about autoimmune diseases. They're incurable and the medications for them are super expensive. God drat it Methotrexate and hydroxchloroquine cost pennies in the civilized world.
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Oct 28, 2020 12:34
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this one is extremely important and deserves close study  https://twitter.com/DrZoeHyde/status/1320755362685808641
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Oct 28, 2020 12:41
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So far in the past 24 hours I've had: 3 people comment how family is flying in for Thanksgiving, or they're doing a big friendsgiving because "its just been too long". 2 people in their 20s mention going to huge Halloween parties this weekend. 4 people comment how packed the gyms (which don't require a mask) have been this week. Mid December gonna be great!
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Oct 28, 2020 14:59
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Wisconsin over 5k cases yesterday and the city next to mine (which is a college hotspot) just decided to reopen the middle and high schools wtf
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Oct 28, 2020 15:17
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Philthy posted:What are the odds 2021 makes 2020 look like a walk in the park. I think the "this is the worst year ever" online meme started in early 2016 when David Bowie and a cluster of other well-liked celebrities died. Little did they know what was ahead. Eta source: https://www.google.com/amp/s/www.bbc.com/news/amp/entertainment-arts-36108133 xtal fucked around with this message at 15:40 on Oct 28, 2020 |
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Oct 28, 2020 15:37
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Noblesse Obliged posted:Is this immune response specific to covid or is this something that can happen with any immune response and this is just sensationalism? the second one
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Oct 28, 2020 15:41
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unpacked robinhood posted:I can isolate just as well in my parents vacant property. People figured selfish parisians leaving the capital were bringing the plague everywhere the first time and nothing happened either. I don't plan on doing any extra doorknob licking or public coughing once I'm there. How can you be so loving dumb. Rich people fleeing cities are a crucial vector in every plague or pandemic. I'm in a fairly insulated community that has seen about 70 infections out of 24,000 people and rich assholes going to their country homes bring it here to our aging population. Stay out, fuckheads.
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Oct 28, 2020 16:06
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